CeeDee Lamb could have one of his biggest games playing against a Lions defense that's tougher against the run than the pass.
DK Metcalf could pose a major big-play threat to Tennessee's injury-challenged corner rotation.
If New England prioritizes defending Travis Kelce then the Pats might not have leftover personnel to cover Rashee Rice.
Erik Siegrist previews the Monday night matchups as the Titans take on the Dolphins and the Packers face the Giants.
The Saints are tougher on the boundary than in the slot, which should provoke a big game from Amon-Ra St. Brown.
The Indianapolis secondary is weakest on the boundary and downfield, where Mike Evans is at his best.
Erik Siegrist previews the Monday night matchup as Joshua Dobbs leads the Vikings against the division-rival Bears.
Playing at home and against the Bears, the Week 11 setup couldn't be much easier for Amon-Ra St. Brown.
DeAndre Hopkins should be able to get rolling against a struggling and injured Tampa Bay corner rotation.
Nico Collins and Tank Dell should come roaring out of the bye week against a battered and weak Carolina secondary.
A.J. Brown and DeVonta Smith are glaring mismatches against the Dolphins corners, setting the stage for a runaway shootout.
Dan Marcus dives into the best IDP options heading into Week 6, starting with the Bengals' Trey Hendrickson, who already has six sacks and seven QB hits this season.
It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
After a slow start through two weeks, Josh Jacobs will likely get more on track against Pittsburgh on Sunday.
Jim Coventry puts down his Monday Night Football Best Bets for the AFC North battle featuring the Browns vs. Steelers, with Nick Chubb in for a busy day on the ground.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
The Colts' cornerback personnel is weak but their run defense is strong, setting up a feast for Calvin Ridley and the Jags passing game.